Endocervical fetal trophoblast for prenatal genetic diagnosis

maoyan64

题名

Endocervical fetal trophoblast for prenatal genetic diagnosis

链接

ABSTRACT For over a decade, methods of first-trimester, noninvasive prenatal genetic diagnosis have been actively pursued by many investigators. Isolation of fetal trophoblast from endocervical specimens remains an attractive approach, given the greater numbers of fetal cells than in maternal blood and the better potential for fetal-cell identification based on markers specific for a single cell type (trophoblasts). Current studies demonstrate feasibility in identification and molecular analysis of fetal trophoblast cells for prenatal genetic testing. Sampling methods involving lavage, cytobrush, or aspiration of cervical specimens, however, have limitations in the recovery of trophoblasts. Clinical applications await further systematic studies to determine safety and accuracy in recovery

求求求求求求求求求

lzaagg

http://sci-hub.cc/10.1097/01.gco.0000192985.22718.17