| 链接 | http://www.ncbi.nlm.nih.gov/pubmed/?term=Oral+and+vaginal+preparations+of+tenofovir+as+pre-exposure+prophylaxis+(PrEP)+for+human+immunodeficiency+virus+(HIV)+infection+have+demonstrated+variable+efficacy+in+men+and+women+prompting+assessment+of+variation+in+drug+concentration+as+an+explanation.+Knowledge+of+tenofovir+concentration+and+its+active+form%2C+tenofovir+diphosphate%2C+at+the+putative+vaginal+and+rectal+site+of+action+and+its+relationship+to+concentrations+at+multiple+other+anatomic+locations+may+provide+key+information+for+both+interpreting+PrEP+study+outcomes+and+planning+future+PrEP+drug+development. |
