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标题: Heparin surfaces: Impact of immobilization chemistry on hemocompatibility an... [打印本页]

作者: 守望 时间: 2014-5-23 17:03
标题: Heparin surfaces: Impact of immobilization chemistry on hemocompatibility an...

题名	Heparin surfaces: Impact of immobilization chemistry on hemocompatibility and protein adsorption
作者	Savannah Gore1, Jonas Andersson2, Roy Biran1,*, Clayton Underwood1 andJohan Riesenfeld2
链接	http://onlinelibrary.wiley.com/doi/10.1002/jbm.b.33154/abstract;jsessionid=F2BE5C07B9084DD386EF990BD2D62B03.f01t02?deniedAccessCustomisedMessage=&userIsAuthenticated=false

本帖最后由守望于 2014-5-24 15:39 编辑

Abstract
Immobilization of heparin to surfaces has been used for decades to reduce the thrombogenicity of blood contacting devices. This study evaluates how the mode of covalent heparin bonding affects the hemocompatibility and uptake of antithrombin on surfaces in whole blood. End-point attached (EPA) heparin, using the proprietary Carmeda® Bioactive Surface (CBAS® Surface), was compared with other methods of covalent heparin bonding that typically yield multiple covalent linkages (using reductive amination of periodate oxidized native heparin or EDC coupling of native heparin). All heparin surfaces were immobilized on flexible polyvinyl chloride tubing and exposed to fresh non-anticoagulated blood in an in vitro recirculating Chandler loop blood model. After exposure, biomarkers for coagulation and platelet activation were analyzed in the solution phase, and adsorbed plasma proteins were eluted from the heparin surfaces and measured for surface concentration of antithrombin and total adsorbed protein. Only the EPA-heparin surface conferred thromboresistance, as observed by the absence of clotting. Attachment and activation of platelets as well as activation of the clotting cascade was significantly lower on the EPA-heparin surface when compared with the other heparin surfaces. In addition, antithrombin constituted ∼40% of the total adsorbed plasma protein concentration on the EPA-heparin surfaces.

作者: cuiwq456 时间: 2014-5-23 17:03
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作者: smart505 时间: 2014-5-23 17:08
你的把题目改成文献名，要不不能应助的

作者: In-June 时间: 2014-5-23 19:07
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作者: cuiwq456 时间: 2014-5-23 19:08
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作者: In-June 时间: 2014-5-23 19:24

cuiwq456 发表于 2014-5-23 19:08
违规帖不得应助

好不容易应助一次。。。

作者: 守望 时间: 2014-5-24 15:14

cuiwq456 发表于 2014-5-23 19:08
违规帖不得应助

题目为啥改不了？第一次求助不太懂，给指点一下吧

作者: cuiwq456 时间: 2014-5-24 15:20
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作者: info 时间: 2014-5-24 15:23

守望发表于 2014-5-24 15:14
题目为啥改不了？第一次求助不太懂，给指点一下吧

点编辑

作者: 守望 时间: 2014-5-24 15:38

info 发表于 2014-5-24 15:23
点编辑

不行，试过了，编辑后点保存还是原来的样子

作者: info 时间: 2014-5-24 15:39

守望发表于 2014-5-24 15:38
不行，试过了，编辑后点保存还是原来的样子

已经帮你编辑了。那是因为你标题超长。看看怎么样子自动截取
http://www.expaper.cn/forum.php?mod=viewthread&tid=47624

作者: 守望 时间: 2014-5-24 15:39

cuiwq456 发表于 2014-5-24 15:20
学习一下http://www.expaper.cn/forum.php?mod=viewthread&tid=47624&extra=page%3D1就会修改了

OK了，谢谢！

作者: cuiwq456 时间: 2014-5-24 15:40
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作者: info 时间: 2014-5-24 15:40
http://www.expaper.cn/forum.php?mod=viewthread&tid=39903

作者: info 时间: 2014-5-24 15:40
http://www.expaper.cn/forum.php?mod=viewthread&tid=35406

再不会我只能呵呵了

作者: cuiwq456 时间: 2014-5-24 15:41
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作者: smart505 时间: 2014-5-24 15:42
1111111111

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